If noise-canceling headphones don’t help you doze off, you may need to consider a more heavy-duty fix: sleeping pills for flights. Certainly, some flights don’t warrant sleeping aids—such as when you’re taking a short trip or traveling west against a time difference, says Aneesa Das, M.D., a sleep medicine specialist at the Ohio State University (at that point you may as well stay awake). But if you’ll be on a plane overnight and waking up in a vastly different time zone, logging some shuteye on the plane is crucial to arriving refreshed—or close enough to it.