In the 16th century, Antwerp, Belgium, with its busy docks along the river Scheldt, was a booming center of trade and one of Europe’s most influential cities, attracting artists, intellectuals and entrepreneurs. In 1576, Christophe Plantin ran a prestigious printing business (one of the continent’s largest) in the center of the city, a half-mile from where, a few decades later, the painter Peter Paul Rubens would build his own studio and semicircular sculpture hall, modeled after the Pantheon. Over the years, while other long-established port cities like Venice and Barcelona evolved into throbbing tourist centers, Belgium’s second city largely kept far away from the spotlight, yet it’s always quietly maintained a reputation as a place for innovation and creative expression. In the 1980s, it became an important fashion hub with the emergence of the Antwerp Six: a group of young designers, including Ann Demeulemeester, who had been educated at the city’s Royal Academy of Fine Arts.